Impaired autophagic function in rat islets with aging
نویسندگان
چکیده
منابع مشابه
Hyperglycemia contributes to impaired insulin response in GK rat islets.
Insulin secretion and glucose metabolism were compared in pancreatic islets from type 2 diabetic GK rats treated with phlorizin or vehicle. Treatment of control and GK rats with phlorizin for 30 days did not affect body weight, islet glucose utilization, or islet glucose oxidation. In phlorizin-treated GK rats, glucose-induced insulin release was about twofold higher at 11.0 and 16.7 mmol/l glu...
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A B S T R A C T The role of calmodulin in insulin secretion from rat pancreatic islets has been examined by the use of trifluoperazine, an inhibitor of calmodulin-Ca++-directed functions. It was found that 30 ,M trifluoperazine caused 50% inhibition, and 100 ,M, up to 73% inhibition of 16.7 mM glucosestimulated insulin release. 100 ,M trifluoperazine caused a similar inhibition of 10 mM glycera...
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Microencapsulation of pancreatic islets before transplantation is a promising approach to enable graft function in an immunocompetent recipient without immunosuppression. However, the insufficient availability of allogenic islet tissue is a major problem. One concept to overcome these shortcomings is the cryopreservation of encapsulated allogenic islets. Recently, we reported a gentle cryoprese...
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ژورنال
عنوان ژورنال: AGE
سال: 2012
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-012-9456-0